Dietmar Porschke, born 1941, PhD under supervision of Manfred Eigen, at the Max-Planck-Institute of Biophysical Chemistry (Göttingen); studies on reactions and interactions of DNA, RNA, proteins and lipids with the goal to understand biological processes. Specificity and dynamics of base pairing. Nucleation length of double helices at 3 base pairs – triplet code represents an optimum between the contradictory requirements of specificity and kinetic flexibility. Analysis of the various elementary steps contributing to base pairing and the hierarchy of coupling. Physico-chemical basis of protein nucleic acid interactions. Identification of contributions and potential relation to the structure of the code. Electro-optical procedures for the analysis of structure and dynamics of macromolecules; macrodipoles; field-induced reactions.
Porschke D, Antosiewicz J (2007) Quantitative molecular electro-optics: macromolecular structures and their dynamics in solution. in “Molecular and collodial electro-optics”, S.P. Stoylov, M.V. Stoimenova eds., CRC, Boca Raton, Fla, pp. 59-107.
Porschke D (1997) Macrodipoles – Unusual electric properties of biological macromolecules. Biophys. Chem. 66, 241-257.
Porschke D (1985) Differential effect of amino acid residues on the stability of double helices formed from polyribonucleotides and its possible relation to the evolution of the genetic code. J. Mol. Evol. 21, 192-198.
Porschke D, Ronnenberg J (1983) An affinity scale for the interaction of amino acid residues with nucleic acids. Biopolymers 22, 2549-2562.
Porschke D, Eigen M (1971) Cooperative Nonenzymic Base-Recognition. Kinetics of the helix-coil transition of the oligoribouridylic-oligoriboadenylic acid system and of oligoriboadenylic acid alone at acidic pH. J. Mol. Biol. 62, 361-381.