Origin of Life

Hans-Joachim Fritz

Last Event

10th June 2016, 16:15
Astrophysical Sources of Energy for Life



Hans-Joachim Fritz, born 1945, earned degrees of "Diplomchemiker" and "Dr. rer. nat." (University of Stuttgart) with work on nucleoside chemistry. In 1974 he joined, as a post‑doctoral fellow, the laboratory of H. Gobind Khorana at MIT to work on problems of chemical polynucleotide synthesis. Starting 1977, he turned his attention to molecular biology, in particular to questions of gene regulation, DNA repair and genetic approaches to protein synthesis ("protein engineering"). He worked at the Institute of Genetics (University of Cologne), later at the Max-Planck-Institute of Biochemistry (Martinsried/Munich). In 1988 he was appointed to the then newly established chair of Molecular Genetics at the University of Göttingen, from which he retired in 2010. HJF has been an ordinary member of Göttingen Academy of Scieneces and Humanities since 1999 and was coordinator of the working group 'Origin of Life' from its inception in May 2011 until June 2013.


Selected papers


Schomacher L, Schurer KA, Ciirdaeva E, McDermott P, Chong JP, Kramer W, Fritz HJ (2010) Archaeal DNA uracil repair via direct strand incision: A minimal system reconstituted from purified components. DNA Repair (Amst) 9, 438-447.


Starkuviene V, Fritz HJ (2002) A novel type of uracil-DNA glycosylase mediating repair of hydrolytic DNA damage in the extremely thermophilic eubacterium Thermus thermophilus. Nucleic Acids Res 30, 2097-2102.


Horst JP, Fritz HJ (1996) Counteracting the mutagenic effect of hydrolytic deamination of DNA 5-methylcytosine residues at high temperature: DNA mismatch N-glycosylase Mig.Mth of the thermophilic archaeon Methanobacterium thermoautotrophicum THF. EMBO J 15, 5459-5469.


Hennecke F, Kolmar H, Brundl K, Fritz HJ (1991) The vsr gene product of E. coli K-12 is a strand- and sequence-specific DNA mismatch endonuclease. Nature 353, 776-778.


Kramer B, Kramer W, Fritz HJ (1984) Different base/base mismatches are corrected with different efficiencies by the methyl-directed DNA mismatch-repair system of E. coli. Cell 38, 879-887.

Selected books


Elsner N, Fritz HJ, Gradstein R, Reitner J (eds.): Evolution. 461 pp., Wallstein, Göttingen 2009. [German].


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